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After inclusion into the study the patients will be randomized to the intervention or usual care group using a computerized randomization on individual patient level.
In this trial, participants 45 years or older with any evidence of established cardiovascular disease will be randomized to the BALANCE or control groups.
In this multicenter trial, 60 newly diagnosed patients with OHS will be randomized to the control (S/T) and trial (AVAPS-AE) groups.
Therefore, participants will be randomized to the treatment groups using a 5 1 ratio, allowing efficient allocation of participants to the IG or CG (respectively) within the online survey group.
Five hundred racially/ethnically diverse, two four year old children and their parent or primary caregiver will be randomized to the multi-component intervention or to a usual care comparison group for a three-year period.
Assuming a dropout rate of 10%, 456 subjects would need to be randomized to the study (228 subjects in each treatment group).
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Of these, two patients dropped out before randomization, and 58 were randomized to the control and 62 were randomized to the continuous glucose monitoring group.
A 2013 study published in JAMA Psychiatry included over 2,600 13- and 14-year-olds in 21 British schools, half of whom were randomized to the program.
Subjects were randomized to the Lung Flute or usual care.
Families were randomized to the intervention or comparison condition.
Twenty-five healthcentresntres were randomized to the intervention or the control group (Figs. 1, 2).
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