Finally, the inclusion of reports where the drug was reported as interacting may be questionable, since this term is often used for pharmacokinetic drug interactions and would therefore have less relevance for a pharmacodynamic effect of the drug.
It should, however, be noted that the reliability of the ratio calculated in indica is questionable since the sequence used to estimate this is yet to be completed.
Third, the approximation of a slightly tilted, flat ground surface is questionable since the actual ground surface topography is more complicated than this.
Also, the value of this procedure as an assessment is questionable, since the testing of only a few of the predictions of the algorithm has a clear anecdotic flavor, especially when the researcher can choose by him- or herself which parts should be presented.
Furthermore the feasibility of such a future study is questionable, since the availability of esophageal balloon and extracorporeal CO2 removal is still limited.
Yet whether treatment with DNA/polyethyleneimine nanoparticles truly induces antigen-specific tolerance is questionable since the response to unrelated antigens was not measured following treatment.
From the ovarian sex steroids, the role of diminishing estrogen levels is questionable, since the levator ani muscle fibers do not express estrogen receptor alpha [ 2, 26].
Therefore, the need for abdominal CT scans is questionable since the detection rate of isolated abdominal recurrences was in fact very low.
Whether CaMKIV would have a similar function in skeletal muscle compared to CaMKII is questionable, since the two proteins have different substrate specificity and intracellular localisation [ 53- 55].
LbrM_V2.1660 is almost identical to gene LbrM_V2.1670, besides harbouring a N-terminal truncation, but this is questionable since the genomic sequence immediately upstream LbrM_V2.1660 is lacking, which renders the determination of the N-terminus uncertain.
