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Our genetic material together with our life style leads to a gradual decline of skin structure and function that can be quantified at molecular, cellular, and organ level by means of modern non-invasive techniques.
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Recent technological advances in electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS), coupled to high performance liquid chromatography (LC), allow lipid diversity and membrane composition to be quantified at the molecular level [ 4– 7].
Data source: GSE3204 We have attempted to address the fundamental issue of "Can the normal physiological states of various human tissue types be quantified at the molecular level faithfully and succinctly?" In the biomedical literature, the phrase "normal physiological state" is often brought up to contrast the phrase "pathological or disease state".
Cellular molecules such as mRNA, proteins and low molecular-weight metabolites can be quantified at 'omics' level, and this information can be mapped onto the corresponding nodes in a bipartite graph representation of the selected bio-molecular interaction network.
First and foremost, he introduced the notion that information could be quantified at all.
The results were quantified at 405 nm using an ELISA reader (Molecular Devices).
DNA and RNA samples were quantified at A260 and A280 using a SpectraMax Plus (Molecular Devices).
Released free fatty acid or glycerol was quantified at 570 nm on a 96-well plate reader (Molecular devices, Mountain View, CA, USA).
Food intake was quantified at 15 weeks.
Proteinuria was quantified at 2.1 g/day.
Solubilized dye was quantified at 550 nm.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com