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However, effective therapy required a third signal which could be provided by exogenous IL-12 or the agonistic anti-OX-40R monoclonal antibody (mAb).
Although DC tumor fusion cells are immunogenic, murine studies have shown that effective immunotherapy requires a third signal, which can be provided by exogenous interleukin 12 (IL-12).
Moreover, sialic acids can be provided by exogenous sources and it is known that cells, be it mammalian or insect cell lines, can use circulating sialic acids to compensate their lack of this monosaccharide [16], [27], [28].
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Neuraminidase activity was provided by exogenous bacterial NA addition for the release of pseudotypes from producer cells.
Because this study aimed to look at the composite nature of neutralizing antibodies responses against different influenza HAs and possibly detect antibody responses against the HA globular head and HA stem region, the NA activity was provided by exogenous bacterial NA.
These data indicated that, even in genetic backgrounds that are not permissive to a protective effect of endogenous androgens, protection can still be provided by supplemental exogenous androgen treatment.
Although proof-of-principle is provided by reports that exogenous Se was shown to decrease hepatic fibrosis in mice [ 155], Se deficiency promoted thyroid fibrosis in a TGF β-dependent manner in rats [ 156].
Additional evidence supporting this hypothesis has been provided by the demonstration that exogenous application of CK enhances germination under abiotic stress conditions [ 8].
More insight into the relationship between speech processing and exogenous attention is provided by a series of experiments conducted by Parmentier and colleagues (Parmentier, 2008, 2013; Parmentier, Elford, Escera, Andrés, & San Miguel, 2008; Parmentier, Turner, & Perez, 2014).
Exogenous perfusion contrast was provided by a 20-mL bolus of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA; Magnevist, Schering AG, Germany), which was followed by a 20-mL saline flush, administered intravenously at a rate of 5 mL/s.
In the 3D environment formed using hydrogel scaffolds in which specific integrin ligation was provided, Stat3 activation by exogenous leukemia inhibitory factor (LIF) no longer acted as a limiting factor for stem cell self-renewal.
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