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However, the efficacy of these reagents in cancer patients still needs to be proven in randomized clinical trials.
However, the benefits remain to be proven in randomized trials.
Nevertheless, this perception remains to be proven in randomized controlled studies.
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The safety and efficacy of bucindolol for the prevention of AF or atrial flutter (AFL) in these patients has not been proven in randomized trials.
19, 20 Still, the efficacy of surgery and nonsurgical tumor ablation has never been proven in randomized trials.
To date, no specific treatment has been proven in randomized controlled trials to prevent or mitigate CIPNM [ 1].
The efficacy of NET with adults and adolescents affected by war and torture has been proven in randomized controlled trials [ 15- 17].
To our knowledge, the advantages of the tension-band plating technique over stapling have not yet been proven in randomized clinical trials.
Although the efficacy of HIPEC has not been proven in randomized controlled trials, the use of this treatment strategy has in recent years been extended to include selected patients with peritoneal carcinomatosis from more aggressive malignancies, mainly colorectal cancer [ 11, 12].
The association of HPV-based screening and vaccination in the prevention of cervical cancer has been proven in randomized clinical trials, but several questions remain about the cost-effectiveness of the vaccine after sexual debut, the impact of non-vaccine HPV types and the best implementation practices [ 29, 30].
However, this concept must be proven in further randomized controlled trials.
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