Millennium researchers think that healthy cells can better recover from proteasome inhibition than tumor cells, though that will have to be proved in larger clinical trials.
The reported aim to implant these endoluminal devices endoscopically must be proved in larger animals but from our point of view the occurence of a symptomatic ileus/subileus will be most likely.
This needs to be proven in large population-based studies.
CT scans, which are typically billed at $500 to $1,500, have never been proved in large medical studies to be better than older or cheaper tests.
For starters, Levine's film holds a mirror up to independent-film life; the story runs on its infrastructure, and the ingenuity of his intricate script is proved in large part by its graceful foregrounding of the background, his dramatic unfolding of the static framework of practical life, of money and of ambition.
Small clinical trials have demonstrated that these therapies are safe and generate significant increases in lung GSH levels, and are associated with positive clinical outcomes including decreased lung inflammation, but their efficacy remains to be proven in larger randomized trials.
In elderly diabetic patients, the use of ACEIs to preclude and slow the progression of renal disease and to prevent kidney failure still has to be proven in large-scale clinical trials.
Every now and then, articles appear in magazines suggesting harmful effects of diagnostic ultrasound but these have never been proved in larger studies.
While Hydralazine was long part of the standard-triple anti-hypertensive regimen (Hydrochlorothiazide, Propranolol, and Hydralazine), it was largely replaced when cardio-protective efficacy of ACEIs and ARBs was proven in large clinical trials (Heagerty et al., 1982).
Doctors caution that no patient should just stop taking any cholesterol drug, because the life-saving benefits of the pills have been proven in large, well-designed studies.
Efficiency and efficacy of organised mammography screening programs have been proven in large randomised trials.
