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On the other hand, given that the marker is determined quantitatively, the approach might be prone to variability owing to incorrect sampling.
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The intensity of peaks obtained in mass spectral data (which is displayed on the y-axis of the mass spectrum), however, are prone to variability.
In addition, the measure of antibody response is prone to variability due to the experimental procedures, such as type of red blood cells or virus preparation.
Given that mass spectra are prone to variability in ionization efficiency, we applied a standardized method of analyzing serum directly with MALDI-TOF MS, using averaging of technical replicates and normalization to a measure of total ionization efficiency by the laser.
Health professional-delivered complex interventions such as ours are prone to variability in the quality of delivery because they are made up of many components and are operator dependent, and this may influence whether they work or not.
Therefore these measurements are known to be prone to significant interobserver variability [ 7- 13].
However, a weakness of the WHO guidelines is the effort needed for manual bi-dimensional tumour measurement of several target lesions, a technique which is also shown to be prone to a high inter-rater variability.
Batch effects have been shown to be a significant concern in microarray experiments [36] and this study could be prone to such effects, given the observed variability across biological and technical repeats (Fig. 1).
There is a direct relationship between instrument reliability and sensitivity to change as instruments that are prone to higher variability between assessments may not detect significant longitudinal change as accurately as instruments with lower between-assessment variability.
But scientists are somewhat cautious in their predictions, given that sea ice is prone to natural variability.
Moreover quantification of beta cell mass using pancreatic sections is prone to substantial variability [ 19].
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