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However, once a weak antimutator allele has arisen to sufficiently high frequency, here denoted as p*, it can be promoted by selection in an effectively deterministic fashion.
Theoretically, female polyandry can be promoted by selection if males provide resource benefits, through the ejaculate [ 10- 12] or through additional paternal care [ 13, 14], or if some males do not provide viable sperm or insufficient ejaculate to fertilize the ova [ 15, 16].
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Cooperative behavior that increases the fitness of others at a cost to oneself can be promoted by natural selection only in the presence of an additional mechanism.
Cases of such adaptive introgression may be promoted by positive selection [ 22], and have been documented in both plants [ 23, 24] and animals [ 25- 27].
Speciation among members of the Anopheles gambiae complex is thought to be promoted by disruptive selection and ecological divergence acting on sets of adaptation genes protected from recombination by polymorphic paracentric chromosomal inversions.
This functional subdivision might be promoted by positive selection [ 35, 36] or be the result of the accumulation of degenerative mutations (i.e., causing a complementary loss of function; the subfunctionalization model) [ 37].
It was suggested that in the marine Cyanobacteria the factors that increase the genome plasticity might not be promoted by natural selection due to the homeostatic environment of the open ocean [ 55].
It can be promoted by the proper selection of suitable plant-microbe combinations and its overall efficiency can be enhanced by adding suitable soil amendments.
Likewise, the observed spatial clustering of DENV lineages on a restricted spatial scale [ 8] may in fact be promoted by location-specific vector-driven selection.
Over longer evolutionary times, phenotypic integration of adaptive trait complexes should be promoted by the evolution of genetic integration via selection on pleiotropic loci responsible for the development of multiple component traits (Cheverud 1996; Wagner and Altenberg 1996).
If a gene is highly divergent, there are two main explanations: first, it may be due to high mutation rate or relaxed selective constraint, in which case the gene may be free to mutate mainly because it has no fitness or function; or second, due to positive selection which is promoted by natural selection and the gene usually has highly important functions [ 45].
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