In Balabushka's case, his entire workshop consisted of a single lathe and other woodworking equipment in the confines of his modest garage, and building his own full-splice butts would have been prohibitively difficult and expensive for him.
Removal by physical means such as riverine, lacustrine, or marine dredging can be prohibitively difficult, expensive, and may not ultimately prove effective.
Randomized trials of whether distinct vector-control interventions act synergistically with each other or with other interventions, such as intermittent preventive treatment or prompt and effective treatment, may be prohibitively difficult for both ethical and logistic reasons.
It was unclear to me how the variants are to be selected and whether veridical can be easily used outside of the Shannon pipeline?" It would be prohibitively difficult for a user and cumbersome to attempt to add such support.
For small domains, like PINs and ubiquitin, this could be prohibitively difficult.
Hastedt, whose group provides legal aid to low-income Mainers, said it can be prohibitively difficult for people with health problems, limited access to transportation, and other barriers to prove that they qualify for an exemption.
Because the derivation and calculation of coalescent likelihoods can be prohibitively difficult, ABC replaces the full dataset with one or more summary statistics.
(The most desirable design, prospectively ascertaining incident infections and subsequently monitoring progression, would likely be prohibitively difficult).
Models should be evaluated against historical observations to check their predictive ability, but identifying and remedying deficiencies of individual-based models can be prohibitively difficult.
