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A limitation of mass-action modeling approaches is the amount of data required to generate specific values for the abundance and rate constant parameters, which can be prohibitive for large scale network reconstructions (Figure 1) [28].
The application of state-of-the-art history matching methods to large heterogeneous reservoirs is hampered by two main problems: (1) reservoir models should be constrained jointly to dynamic data and a large variety of geological continuity information, and (2) CPU demand should not be prohibitive for large models.
The result emphasizes the potential role of well-designed adaptive studies in the context of imaging studies where high patient costs may be prohibitive for large trials.
ABrowse renders all data to tiled images, but cannot zoom smoothly and requires custom data to be fully uploaded to the server which can be prohibitive for large datasets.
However, even a few iterations on the entire dataset can be computationally expensive, particularly in terms of memory requirements; the posterior probability distribution requires storage, which can be prohibitive for large datasets.
This is true for practical reasons (estimating phylogenies takes time, and may be prohibitive for large numbers of groups), and for analytical reasons (there is a reduced amount of data in small clusters of sites, so phylogenies may be inaccurately estimated; it is better to focus the power of the smaller datasets on estimating only the substitution rates).
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Besides, its complexity can be prohibitive for large-size network with dense deployment of PBSs and peak traffic time.
Traditionally, eigenvectors can be obtained via spectral decomposition algorithm, SVD on S or ED on G. Nevertheless, they are prohibitive for large L. Here, we introduced two different approximate spectral decomposition methods for large dense matrices: Nyström method [11 15] and Column-Sampling approximation [14 17].
Although feature selection is integral to each of these analytical tasks, an exhaustive search of all 2 n −1 possible feature subsets is prohibitive for large n.
In either case, the computational expense is prohibitive for large-scale problems.
Hence, the ML decoding (2) has the complexity, OML=2K, which is prohibitive for larger values of K.
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