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The significant differentially expressed proteins identified in this study should now be progressed to a much larger double-blind, multi-centre biomarker trial for further validation of their potential as "combinatorial signatures" of Dukes' stage-specific CRC.
If up to 3 months of metformin monotherapy does not enable the individual to reach the HbA1c target, they should be progressed to a two-drug combination of metformin with a sulphonylurea, thiazolidinedione, dipeptidyl peptidase-4 inhibitor, glucagon-like peptide-1 receptor peptide-1 receptornsulin.
This is a powerful approach, however it is usually aimed at a limited number of targets and a small number of compounds at the decision-making point when the hit is ready to be progressed to a lead (Azzaoui et al., 2007; Whitebread et al., 2005).
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Two compounds from this series were progressed to a 5-day diet-induced obesity mouse screening model to evaluate their potential as weight loss agents.
"It's progressed to a point now where it's like 'OK, let's put an adult star in there as well' because they have a fan base already and it creates that little bit of taboo.
Hopefully, we're progressing to a more utopian reality, but getting there is not easy.
The quarterback's recovery appears to be progressing at a superhuman pace.
In this case, the investigation, which regulators say is continuing, progressed to a complaint within six weeks.
It is progress to some, a shock to others, says another.
It will be progressed over the program to maintain a moderate intensity.
Thereafter Marchant and Browne were unbeaten and progressed to an unlikely Olympic gold.
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