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"The matter cannot be progressed further until the required information is forthcoming.
Removal of all nitrogen protecting groups from 4 b allowed the selective dimethylation of the α-nitrogen atom by reductive amination using aqueous formaldehyde and sodium cyanoborohydride.[ 12] Reprotection of the guanidine moiety afforded 4 a in 35%% yield (3 steps) and minor amounts (13 %) of regioisomer 28 which could feasibly be progressed further if desired.
If this is determined intra-operatively, patients will not be progressed further into the study; 5) Medical/Anaesthetic contraindications to surgery; 6) Unable to comply with rehabilitation or attend follow up appointments as determined at the time of surgery (e.g. resides internationally); 7) Are currently pregnant.
High-throughput screens for multiple targets provide large amounts of data, and novel means are needed for turning this into meaningful information to support flagging-up of potential negative side effects that warrant further investigation in subsequent studies, or indeed to identify drug candidates that should not be progressed further.
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Once the potential drug molecule has been selected or identified, it is progressed further for the process of drug development.
It's nice to be in a new sport and every time you train you think: 'Ooh, I'm progressing further and really getting the technique.'" Alphonsi has been coy about how far she's actually throwing since joining coach Tracey Quartey in November, refusing to measure her throws in training.
Compounds that were active in both mGlu8 assays, but did not induce responses in cells lacking mGlu8, were progressed for further study.
It also recommended Thames Estuary airport proposals were not progressed further.
It was just that we weren't progressing further.
If Chivas are to progress further they'll need to break another pattern - they now travel to a Seattle team unbeaten in 20 US Open Cup games.
When biologics were used, if there was C-spine subluxation, 79%to80%0% progressed further [ 64, 65].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com