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Our results are in agreement with a report by Persson et. al that show other vault RNAs (vtRNA-1) can be processed to smaller functional counterparts through a Drosha-independent but dicer-dependent mechanism [21].
The present report serves as a starting point and ready reference to a dataset which suggests that a subset of lncRNAs could potentially be processed to smaller RNAs.
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For example, they may be processed to small regulatory RNA molecules such as miRNAs.
We hypothesized that some lncRNAs could potentially be processed to small RNA and thus could have a dual regulatory output.
Recent reports have suggested the role of small nucleolar RNAs (snoRNAs) in having dual functional output by virtue of being processed to smaller RNAs [ 20, 21].
Within the bone marrow, the beta-glucan molecules were processed to small soluble biologically active fragments.
With the aid of experimental design methods, the mean particle size of the primary pigment powders can be processed to as small as 46 nm.
Moreover, we did not succeed to predict any stable RNA secondary structure associated to a putative precursor sequence that might be processed to generate the smaller product.
What was most interesting in relation S. pyogenes is that there were differential SpeB activities on the closely related ELR-negative CXC-chemokines CXCL9, CXCL10, and CXCL11, where CXCL9 was processed to a smaller fragment rather than being degraded, CXCL10 was almost completely degraded, and CXCL11 was completely degraded.
It is known that scaRNA 2, 9 and 17 are processed to generate smaller fragments (Tycowski et al., 2004), but how this is accomplished is unclear.
Both scaRNA 2 and 9 are processed to yield smaller fragments that guide modifications on U2 snRNA (Tycowski et al., 2004).
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