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Caspase-1 is crucial for processing of intracellular pro-IL-1β, although extracellular pro-IL-1β can be processed by several proteases, including serine proteinase 3 and the metalloproteinases MMP-2 and MMP-9 [ 33, 34].
These fragments are either intermediated of APP degradation in lysosomes, or are produced by processing of APP in regions NH2-terminal to the BACE1 cutting site, suggesting that the APP ectodomain can be processed by several unknown proteases, in addition to α- and β-secretase.
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The data given as input is processed by several small processors that run in parallel.
Experimental conditions such as pH, reagents and citrate concentrations were optimized, and the data obtained from the experiments were processed by several chemometric approaches, such as artificial neural network (ANN) and partial least squares (PLS).
Each speech file pair is processed by one or several signal-based models.
Subsequently, overexpressed C99 was processed by γ-secretase releasing several proportions of Aβ42 and Aβ40.
Aβ is a cleavage product of the amyloid precursor protein (APP), which is sequentially processed by several proteases, the so-called secreatases α, β and γ.
When the news reaches our ears, it is then processed by several brain regions including the brain's sensory relay station (the thalamus), the primary fear-expressing nucleus (the amygdala), and our the cortical areas that are responsible for inhibiting or suppressing fear (the prefrontal cortex).
This polymer is further processed by several membrane and periplasmic enzymes to ultimately create the peptidoglycan.
12, 13 A key active intermediate, 5-hmC is further processed by several pathways back to unmodified cytosine (Fig. 2).
During terminal differentiation this protein is dephosphorylated and processed by several endoproteases to generate two major products: FLG and the N-terminal peptide [27].
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