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The terminal sequence motifs can be processed by posttranslational modifications, thereby providing a means to increase sequence diversity and to regulate interactions.
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Full-length MAP1S (FL) is processed by posttranslational modification to multiple isoforms that include heavy chain (HC), short chain (SC) and light chain (LC) [ 7, 11, 18].
The raw data were converted into peak-list (PKL) files that were processed by MASCOT (www.matrixscience.com) for searching proteins and protein posttranslational modifications sites.
In some cases, ADP-ribosylarginine is processed into secondary posttranslational modifications, e.g. phosphoribosylarginine or ornithine.
Citrulline can be formed by posttranslational enzymatic conversion of arginine residues, catalyzed by peptidylarginine deiminase enzymes.
Importantly, BAG3 function and levels can also be regulated by posttranslational modification.
Several proteins involved in miRNA processing are regulated by posttranslational modifications (PTMs).
Proteins that interact with modified histones can also be regulated themselves by posttranslational modifications [10].
The transcriptional activity of FoxO1 is regulated by posttranslational modifications, such as phosphorylation, acetylation and ubiquitination, altering, for example, its subcellular translocation between the nucleus and the cytoplasm30,31.
The activity of DRP1 is regulated by posttranslational modifications.
Similarly to p53, p63 is affected by posttranslational modifications.
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