Sentence examples for be problematic when using from inspiring English sources

Multi-domain proteins can also be problematic when using Position-Specific Score Matrices (PSSM) in probabilistic inference analysis as used in HMMER3 [33].

The restriction of follow-up to 5 years enabled the efficient computation of these complex models, which can be problematic when using this approach for analyzing large population-based datasets with long follow up intervals [ 33].

Multiple hot/cold spots would seem to be problematic when using the scan statistic, since it uses a likelihood function from a model based on a single hot or cold spot only.

The use of accelerometry to quantify PA/ST is especially important since self-report measures have been found to be problematic when used with culturally and linguistically diverse groups [ 44, 45].

Slush nitrogen (SN) is used to avoid the Leidenfrost effect, which is problematic when using liquid nitrogen (LN).

Preliminary trials revealed that this method was problematic when using small spiders because, at 50 mm away, small spiders often seemed not to notice the virtual mosquitoes and, when closer to the screen, the tube cast a shadow on to the screen.

Second, 29% of patients managed using BAL had new antibiotics initiated within 3 days before randomization, probably after the onset of the first signs in relation to VAP, which is problematic when using quantitative culture techniques.

Phylogenetic reconstruction of trees including endosymbiotic DNA sequences which are strongly AT-biased and evolve at relatively high rates is problematic when using classical models of DNA sequence evolution.

The microsatellite DNA locus HaD47 (GenBank: AY497338) [ 9] with its reverse primer designed within the LSCS1 is problematic when used in population genetic studies [ 15] (but see [ 50]).

Our analysis demonstrates that the interpretation of 'outcomes' that may be appropriate for clinical trials of pharmaceutical products, is problematic when used in evaluations of complex interventions in areas such as complementary medicine, palliative care, rehabilitation, and health promotion.

Although this might not be problematic when "AKI" is used as a diagnostic classifier, it can have an influence on the prognostic value of the label "AKI".