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Smoking exposure is known to carry its own health risks, and when the cancer survivors and controls are not matched on this variable, it may be problematic to separate the effects of cancer treatment from those of smoking exposure.
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Although we were aware that it is quite problematic to separate these nested RCT from the non-RCT, we nevertheless decided to do so.
"It would have been very problematic to separate the bogs of the middle, since the bogs are so dependent on the water supply," Ms. Byers of the Conservation Foundation said.
"It's problematic to draw a rigid line separating breast-feeding and sexuality," said Noelle Oxenhandler, the author of "The Eros of Parenthood".
The implications for ExxonMobil are problematic, to say the least.
It was problematic to say the least.
Separating a carbene from a carbene-metal complex can be problematic due to the stability of the complex.
This could be problematic considering that a separate loading area was only available at 50% of the farms.
The input for this MatrixConverter can be either a tab-delimited text file (*.txt) or a CSV file of morphological characters (although note that the CSV format may be problematic if commas are used to separate multiple character states for a polymorphic character).
Importantly, direct comparison of costs of mating for both sexes requires a common measure of reproductive investment, which is problematic in separate sex species.
Undeniably, it's going to be problematic".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com