In regions where the scale of heterogeneity is smaller than the traditional 3 5 km averaging length, it has been problematic to relate measured flux signals to an individual land use.
Between-city comparisons are subject to potential confounding because covariates may be highly correlated with air pollution, whereas time-series studies are problematic to interpret because they relate short-term changes in air pollution that are driven primarily by meteorology to outcomes.
These structures have been problematic to interpret (or usually not recognized) as authors have been unclear how the buccal lophs are related to tribosphenic cusps.
Older people with chronic physical illnesses and depression may be difficult to recruit because motivation may be problematic, as related to their mood difficulties.
Moreover, chimerization may be problematic between closely related species, but less severe for more distant organisms.
In routine clinical practice in the UK, combining these treatments in a timely fashion could be problematic for practical reasons related to the skills of practitioners and service issues such as waiting lists for physiotherapy.
This exemplification could be problematic as the patients could relate to them as if they were the stressors that they should report.
However as long term administration of 6TG is problematic due to dose related toxicities, such as veno- occlusive disease, this study will assess the activity of 6-mercaptopurine (6MP), which is converted to the same active moiety, 6-thioguanine nucleotide, prior to incorporation into DNA.
The statistical tests are problematic because related individuals are not independent of each other, but there was no clear tendency for any specific locus to show departures from the expected Hardy-Weinberg frequencies.
This can be problematic because public fire policies, which relate to fires of all sizes, are influenced more by the way the media portrays catastrophic wildfires than by small fires.
