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A significant source of false-positives for this method comes from the fact that dual out-edges can be created by genome structure that is not just a SNP- any pair of k-mers that differ by a single end nucleotide causes the key bifurcation thus repeats, inversions and other low-complexity genome sequence can be problematic to differentiate from the desired SNPs.
Similar(59)
Furthermore, it is problematic to differentiate the particle from the background fluorescence.
It is tough to differentiate legitimate good links from bad.
It was problematic to say the least.
"Rogue apps can be hard to differentiate from real apps.
I had to be careful to differentiate the voices.
Rubio's lieutenants proved to be problematic.
They turn out to be problematic.
Undeniably, it's going to be problematic".
This view is perceived to be problematic.
Classification also turns out to be problematic.
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CEO of Professional Science Editing for Scientists @ prosciediting.com