Sentence examples for be problematic in particular from inspiring English sources

However, focusing the screening library entirely on active compounds might be problematic in particular when only few, structurally similar active compounds are known or when the identity of the biological target is unknown (see below).

In post-mortem samples, differentiation of post- and intra-ictal neuronal necrosis from terminal ischaemic changes can be problematic, in particular if prefinal seizure episodes might have gone unseen.

The absence of effective measures on a larger scale is problematic in particular with regard to contaminated drinking water reservoirs.

Thus, the option of next therapeutic strategies is problematic in particular with regard to its insensitivity to various standard chemotherapies.

This state is problematic, in particular in microfluidic microsystems where the displacement of a drop with a hysteresis of 100° is not easily realizable.

In practice the latter approach is problematic, in particular since there is no clear consensus on the mapping between the skill content of occupations, as measured by the GED scale, and years of schooling (Leuven and Oosterbeek 2011).

A manual inspection of the data, however, showed that this approach is problematic in particular in those cases where RNAz scores are high for both reading directions.

This is problematic, in particular if one is dealing with a long-branch taxon, such as Tardigrada, the position of which is ambiguous, as evidenced by conflicting topologies published each year [ 2- 4, 7, 10- 16, 16].

This is problematic in particular in light of the growing amount of research taking place in Africa, and with the rise of biobanking practices also on the African continent.

We agree that the term is problematic, in particular as it originates from physics with a different meaning: "A phase transition is the transformation of a thermodynamic system from one phase or state of matter to another one by heat transfer".

In view of regional differences in the starting point of screening programmes around Spain, extracting conclusions based on incidence would be problematic in this particular period.