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Although the sample size was large, violations of normality can be problematic in estimating rates of change using maximum likelihood estimation [ 51].
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The reason is the tight amount of degrees of freedom in which this analysis is conducted, which would be problematic in case of estimating Eqs.
This may be problematic in certain contexts.
This can be problematic in regression equations.
Hypertension can be problematic in PAN.
Migration is problematic, especially in estimating populations for small areas.
Estimating connectivity is problematic in marine species with long pelagic larval stages that have potential for long-distance dispersal (Roughgarden et al. 1988; Mora and Sale 2002).
Error estimation is problematic in small-sample classifier design because the error must be estimated using the same data from which the classifier has been designed.
Also, conventional approaches for estimating internal PCR parameters are problematic in low capacity PCR machines.
A common solution has been to employ various convenience sampling methods which, although clearly viable with respect to accessing these populations, are problematic in terms of generating conclusions or estimates that are generalizable to the population from which the sample was obtained.
These substitutes for tax rates, however, are problematic in that they introduce a significant downward bias in estimates if potential endogeneity bias is not dealt with.
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