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The presence of agglomerates during nanopowder sintering can be problematic and can limit achievable final densities.
Defining whether a particular SNP is part of, or regulates a gene can also be problematic, and can result in functionally important trans-regulatory SNPs being missed and will also miss the effect of SNPs in gene deserts.
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There is no need to travel by car to reach interesting cities in Lombardy and the Veneto, where finding parking is problematic and can be expensive.
Theoretical materials from a number of fields suggest that regulatory approaches requiring people to adhere to certain rules are problematic, and can result in worse outcomes.
They are excited about the work and are eager, yet it seems to be burdensome, which is problematic and can halt collaboration and iteration.
However, the data transfer to surface is problematic and can only be done discontinuously (Huenges 2013).
This disjunction is problematic and can compromise effectiveness.
There has to be an acknowledgement that the very term 'commissioning' is problematic and can be a 'turn off', particularly for the clinicians who may be at the heart of the process, either as commissioners or as deliverers of care.
We have deleted the Van't Hoff plots because we agree that the precision of the occupancy estimate is problematic and can potentially be obscured with increasing B-factors.
While colinearity in multiple linear regressions is problematic and can lead to inaccurate predictions, Nimrod/E is able to circumvent this problem and successfully identify both main effects and multifactor interactions [ 28].
Communication of DST results between central and local laboratories and clinical facilities can be problematic and results can take several months [ 2] to get to their destination or never arrive [ 3], especially in high-burden countries with limited infrastructure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com