Sentence examples for be prion from inspiring English sources
noun
A self-propagating misfolded conformer of a protein that is responsible for a number of diseases that affect the brain and other neural tissue.
It is possible that the effect of clusterin on incubation may be prion strain specific and an association may be seen with other strains particularly BSE.
Many proteins have been proposed to be prion receptors [54] and it seems likely that glimepiride treated cells express some of them, or that PrP82 146 binds to cells independently of specific protein interactions.
Furthermore the data presented here showing that depletion of nucleic acids from the PrPC substrate of a mouse adapted model of human prion disease prevented PrPres formation, indicates that the requirement for endogenous RNA may be prion strain dependent.
In addition to the brain and other organs known to be prion positive in vCJD, such as the lymphoreticular system, pituitary and adrenal glands, and gastrointestinal tract, PrPres was also detected for the first time in the dura mater, liver, pancreas, kidney, ovary, uterus, and skin.
Another situation where neuron death remains a highly plausible (if still unproven) source for elevated CSF-tau may be prion diseases such as Creutzfeldt Jacob Disease (CJD), which typically features much higher CSF-tau levels than does AD together with massive neocortical neuron loss over a shorter timecourse after diagnosis.
Previous reports have found this trend in the genomes of yeasts in which these repetitive stretches are generated by DNA tandem duplication [ 48] rendering protein domains that were thought to have no function [ 49] but that according to our results might indeed be prion domains involved in homeostatic processes.
The regularities in the likelihood of the identified PrDs to be prions, and their distribution among different viral orders and families were analyzed.
Adult mule deer killed by mountain lions were more likely to be prion-infected than were deer killed more randomly in sympatric populations, suggesting that mountain lions were selecting for infected individuals when they targeted adult deer.
Truncation of disease-related PrP by this activity appears to be prion-strain specific [ 24], and these results indicate that the conditions for digestion with thermolysin should be optimized empirically for different prion strain/host combinations.
Minor point: "Abnormal prions" should be "prions", because prions all are abnormal.
One substance removed is prion protein, the cause of CJD.
