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Despite these line specific differences, both AJ reduction and glial expansion seem to be primary consequences of the loss of Crb1 that contributes to an even weakening of the OLM across the superior and inferior retina.
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These data have to be carefully evaluated when used to monitor disease evolution [45], as penetration of death probes might be a primary consequence of membrane permeabilization during isolation rather than a physiological feature of the disease [46].
Prominent among the biological processes identified by pathway analysis in another study, performed two weeks after SNL, were functions such as neurite outgrowth and neuronal development, suggesting these effects to be among the primary consequences of SNL injury [37].
However, one Glasgow-based study found students (of either sex) strongly expected aggression to be a primary consequence of alcohol use, particularly in males (Crawford, 1984).
The data suggest the possibility that reduction of cell senescence may be a primary consequence of DR which in turn may explain known effects of DR such as improved mitochondrial function and reduced production of reactive oxygen species.
It is unclear whether this is the primary consequence of fluid therapy per se, or reflects the severity of illness.
26 Whether complex I deficiency is a primary consequence of the disease or a secondary adaption is a question that remains to be addressed.
However, we cannot rule out that the ruptured Z-discs are the primary consequence of Mena/VASP double-deficiency and that clustering of αII-Spectrin and β-actin are secondary effects.
The development and progression of secondary hyperparathyroidism are the primary consequence of this elevated serum phosphorus.
Sudden cardiac death is the primary consequence of coronary artery disease in 50% of men and 64% of women.
To examine whether cell invasion is a primary consequence of Src42A activation, or a secondary effect of cell death triggered by elevated Src activity, we expressed the caspase inhibitor p35 to block cell death.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com