Under specific cellular conditions, miRNA-mediated repression was prevented or reversed, and the inhibitory effect of miRNAs was modulated by RBPs acting on the same mRNA.
Pharmacologic agents and physiologic manipulations that were found to prevent or modulate synaptic plasticity often affected slow oscillations themselves as well, and it is unclear whether the effects were due to direct actions on the fundamental mechanisms underlying synaptic plasticity or simply due to indirect effects via the altered slow oscillations.
Neutralizing antibodies play an essential part in antiviral immunity and are instrumental in preventing or modulating viral diseases.
Lowering the ratio of n-6 to n-3 FA in food products have been recommended to prevent or modulate certain diseases in humans [ 38].
"And dentists, who have to deal with trying to prevent or modulate pain, will be impressed".
The paradigm proposed here, if proven, spells out a sequence of steps, one or more of which could be interdicted or modulated early in carcinogenesis to prevent or, at a minimum, slow down the progression of many cancers.
These movements can be enhanced or modulated further by auditory and visual input.
In DNA damage response, the function of hnRNP K in p53 activation has been reported to be modulated by sumoylation, which enables the protein to function as p53 cofactor or prevents HDM2-dependent ubiquitination and proteasomal degradation of hnRNP K.
It remains to be determined whether other biological factors described to modulate neurogenesis in the aged brain (see Table 3) could be useful in preventing or curing the development of memory disorders during the course of aging.
Our work provides a new perspective for understanding how evolution might result, for functional reasons, in regions characterized by a significant fibrillogenic tendency, and suggests a protection mechanism through which aggregation can be modulated or even prevented.
