The incremental cost per active TB case prevented, compared with no screening, was ₤ 47,840 in TST, ₤ 39.712 in T-SPOT.TB, ₤ 42,051 in QFT.
We then applied the risk reduction from cessation to estimate the number of deaths that would be prevented and compared this with those prevented in non-small cell lung cancer and small cell lung cancer populations as estimated in this review.
The randomized trials have compared usual care diabetes regulation with intensive regulation, but it is still possible that cardiovascular events could be prevented when comparing poor regulation with good regulation.
Based on inputs derived from systematic literature reviews, the model has shown that 47 CV events and 10 CV deaths could be prevented in the UK with the polypill compared with multiple monotherapy per 1000 patients over 10 years, at an ICER of £8200 per QALY gained.
This translates to an absolute risk reduction of 8%, meaning that one wound infection would be prevented for every 13 people treated compared with no administration of antibiotics.
Falls can be prevented with targeted interventions.
Overall, knowledge about how HIV is transmitted and can be prevented fell to 26.8% in 2012, compared with 30.3% in 2008.
More than twice the number of deaths could be prevented by simvastatin therapy among the elderly compared with the younger subgroup (61.5 vs 25.5 [all-cause] and 60.2 vs 28.1 [CHD] per 1000 patients).
For the high-risk diabetes prevention intervention, we estimated that in 2025, almost 130,000 cases of diabetes could be prevented, or 6.4% of all diabetes cases compared with the projected status quo scenario.
