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We provide in-patient proof that the observed "on-target" toxicity is antigen-directed and can be prevented by blocking antigenic sites in off-tumor organs and allowing higher T cell doses.
The expansion seen in autoimmune prone animals can be prevented by blocking CD40 CD154 interactions [4].
However, the disrupted homeostasis in autoimmune prone NOD mice can be prevented by blocking CD40 CD154 interaction [4], [5].
We used a novel xenograft mouse model to directly determine if bone pain could be prevented by blocking the known cleavage of the A6 integrin adhesion receptor.
T cell inactivation by MHCI can be prevented by blocking the T cell receptor's signaling cascade with an antagonist (Rp-cAMPS) of cAMP-dependent PKA [28], [34].
Importantly, we found that dopamine, but not dopamine agonists, induced conformational changes in α-synuclein which could be prevented by blocking dopamine transport into the cell.
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Spreading was inhibited by blocking stretch-activated channels (with gadolinium), while retraction was prevented by blocking the L-Type voltage-gated channel (with nifedipine); both compounds inhibited MT1-MMP upregulation.
In particular, the analysis results of fiber size showed that the acceleration of muscle regeneration in RNF13-/ mice was prevented by blocking IL-4 and IL-6 eliminated (Fig. 5B and 5C; compared with IgG control).
First, disulfide bond scrambling is prevented by blocking free thiols with N-ethylmaleimide (NEM) and by maintaining an acidic pH throughout the sample preparation process, the latter of which includes precipitating freshly prepared protein samples with trichloroacetic acid (TCA) as early as possible and carrying out all protease digestions at pH 6.5 (Fig. 1).
Radialization of vimentin+ radial glia mediated by NRG1 was prevented by blocking erbB3 or erbB4 receptors (Figure 6E,F,H).
The invasive behavior induced by P or MPA was prevented by blocking PR, G proteins or ROCK-2 (Fig. 10A B).
More suggestions(15)
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