Having examined gene expression signatures within individual datasets, we questioned whether these signatures were preserved across different tumour types.
In this work we present methods a) for finding consensus modules across multiple networks, b) for describing the relationship between consensus modules (eigengene networks), and c) for assessing whether the relationship between consensus modules is preserved across different networks (differential eigengene network analysis).
Interestingly, several of the identified differentially regulated miRNAs during AD differentiation of hMSC have previously been reported to regulate hMSC differentiation (e.g., miR-222, miR-138 and miR-30 family), indicating the importance of the regulatory network controlled by miRNAs as they are preserved across different cellular models of MSC.
These results show that meta-modules may or may not be preserved across the different eigengene networks.
Our method draws on image edge line segments and perspective information to generate the quadrilateral features, as edges are likely to be preserved across these two different modalities (Coiras et al. 2000; Dana and Anandan 1993).
However, it is not clear how such an organisation might be preserved across the multiple auditory fields of primate cortex where different fields show different orientations of the tonotopic gradient.
At a local scale these syntenic relationships should be preserved across taxa [ 33].
The most striking gender disparities in psychopathology are preserved across populations, of different ages or income levels.
Indeed, larger neurons with larger numbers of synapses in culture have recently been found to have sparser connectivity and reduced unitary synapse strength, such that firing rate was preserved across clusters of different sizes [61].
Essential aspects of morphometric appearance and complex dendritic integration critical to CA1 pyramidal cell functioning are preserved across neurons defined from the two different hippocampal preparations used in this study.
