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The second layer of nodes corresponds to the fragments that are set in the fingerprint for the reference structure, and which are hence expected to be present in active molecules (by the similar property principle).
CXCL13 was shown to be present in active inflammatory lesions in MS [12].
CXCL13 was found to be present in active MS lesions and to be elevated in CSF of MS and CIS [11], [12], [13].
In addition, the association should be present in active but not resolved disease.
Subepithelial humps, specifically, favor the diagnosis of IgA-dominant PIGN, but can also be present in active IgAN [ 4].
Focal tubulitis can be present in active disease, and tubular atrophy and interstitial fibrosis characterize chronic renal disease, contributing to impaired renal function.
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As assessed by fluorescence microscopy activated microglia characterized by their amoeboid morphology were present in active lesions in close proximity with granular myelin debris.
Hu et al. [17] present an approach that improves search results by employing only fragments that are present in active compounds.
Comparison of its putative antiprotease loop with positions P6-P5' of known inhibitors showed that analogous amino acids are present in active molecules: the chymotrypsin inhibitor from Bungarus fasciatus has Asn in P1 and is similar over the P-side of the loop; the trypsin inhibitor from Daboia russelli bears equivalent residues in P2' and P4' (His and Arg) (Figure 5A).
only MMP-2 was present in active form.
The present study provides further evidence for this concept by showing that two distinct and stable HPO42−/H2PO4− ratios are present in active cells of K. stuttgartiensis.
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