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Tenofovir's IVTI activity is supported by the preliminary finding that genes reported in two recent studies to be preferential sites of HIV integration after periods of ART appear to overlap with genes inhibited in our studies by tenofovir.
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It has been unambiguously demonstrated that the Golgi apparatus and ER are preferential sites of Foscan® accumulation.
Our data therefore demonstrate that telomeres are preferential sites of oncogene-induced DNA replication stress when compared with the rest of the genome.
Note that RNAPII transcription initiating preferentially at purines, the A and G of the annotated start codons are quite frequently used as sites of transcription initiation and the first nucleotide of codons are preferential sites of internal initiation because these positions are enriched in purines.
If NRTIs do indeed promote latency, then high drug concentrations would make the small intestine favorable for HIV latency, consistent with the observation that within the gut the duodenum and ileum were preferential sites of residual HIV DNA and unspliced RNA in ART-suppressed patients.
Boundaries of primary α grains were observed to be preferential sites for crack nucleation and provide easy path for fracture propagation.
In parallel, the zones around the high-angle SGB free from exsolution lamellae are preferential sites for recrystallization of small grains (Figure 9c).
Such locations are preferential sites for formation of sedimentary river basins (e.g. the Amazon basin) or for deposition of rocks (e.g. during the Mesozoic in South Sweden).
Due to their high primary productivity, abundant detritus, rich organic matter and anoxic/reduced conditions, the mangroves are preferential sites for the uptake and preservation of PAHs, resultant of high anthropogenic impact (Bernard et al. 1996).
Therefore, the intensity ratio can be used to evaluate the formation of defects which are preferential sites for functionalization.
The bones around the knee and the proximal ends of the humerus and femur were preferential sites.
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