These individuals are predisposed to development of benign leiomyomas of the skin and uterus as well as highly aggressive kidney cancers (Launonen et al, 2001; Tomlinson et al, 2002; Wei et al, 2006).
It has also been reported that women with a metal-on-metal resurfacing arthroplasty are predisposed to development of periprosthetic pseudotumors with extensive connective tissue necrosis and mainly lymphocytic infiltration (Pandit et al. 2008).
In this report we conducted proof-of-principle studies by cross-breeding transgenic mouse strains known to be predisposed to the development of mammary gland tumors, the MMTV-neu [18] and Beclin1 +/− [19] mouse strains, with the ODD-luciferase mice developed by Safran, et al. and subsequently characterized tumors via bioluminescent monitoring.
This finding raises the possibility that subjects with DPN may be predisposed to the development of DFU in part because of specific impairment of skin quality.
This cell type might be predisposed to tumor development in the zebrafish, or the MPNSTs and SRBCTS might both be able to arise from the same type of nerve sheath cell.
We reasoned that examining the mutational spectrum of patients with intellectual disability and the mutations related to carcinogenesis may shed light on whether the patients with intellectual disability might be predisposed to tumor development.
In light of the current literature, we anticipated overweight girls with CYP19A1 hypomethylation and PPARG hypermethylation might be predisposed to early breast development [ 33- 35], and those with PPARG hypermethylation to early pubic hair development [ 9, 16].
Transgenic mice containing homozygous mutations of the HOXB13 gene, in contrast, do not appear to be predisposed to prostate cancer development (Economides and Capecchi, 2003).
Young athletes may be predisposed to FAI because of the stress on the physis during development.
I could even be predisposed to some potentially devastating disease.
