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Several autoantibodies have now been shown to be predictive of type 1 diabetes (T1D) (1– 8).
Glucose levels at intermediate times have been shown to be predictive of type 1 diabetes (6, 7).
An autoantibody to zinc transporter 8 has recently been found to be predictive of type 1 diabetes in children (12).
In a follow-up study, a synergistic elevation in circulating levels of IL-1β and IL-6 was suggested to be predictive of type 2 diabetes (44).
In addition, fasting glucose levels and glucose levels at various OGTT time points have been found to be predictive of type 1 diabetes (7, 9).
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Apolipoprotein A1 ApoA1) and apolipoprotein B (ApoB) are the major parts of the protein moieties of HDL and low density lipoprotein-cholesterol (LDL-C), respectively [ 5]. High concentrations of ApoA1 were found to be predictive of type-2 diabetes in Turkish adults [ 6].
The data indicate that the number of autoantibodies is predictive of type 1 diabetes.
Within the positive range, GAD65 and ICA autoantibody titers were predictive of type 1 diabetes.
Thus, we studied the extent to which specific autoantibodies are predictive of type 1 diabetes.
In addition to being predictive of type 2 diabetes mellitus (T2DM), pre-diabetes is associated with increased risk for developing cardiovascular disease (CVD) [ 2, 3].
All variables in the DPTRS model were predictive of type 1 diabetes in the TNNHS (P < 0.01), except for fasting C-peptide (P = 0.075).
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