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In this regard, the mesial temporal atrophy (MTA) score, a radiologic measure for the degree of hippocampal atrophy, has proven to be predictive of progression from mild cognitive impairment to AD [20] and can identify patients with AD with an accuracy and sensitivity of approximately 85% compared to healthy controls [21].
In particular, the frontal and temporal cortical thinning in PD-MCI may be predictive of progression to Parkinson's disease dementia.
It has also shown the ability to demonstrate changes in morphologically intact cartilage that may be predictive of progression to OA [ 44].
The timing of the peak C-peptide was also found to be predictive of progression to type 1 diabetes mellitus in the Diabetes Prevention Trial [ 42].
For example, among African Americans compared with Caucasians [ 46], we have reported a higher prevalence of specific radiographic features, such as superior joint space narrowing, previously found to be predictive of progression to hip replacement [ 47].
We defined prediabetes among individuals without previously diagnosed diabetes using HbA1c cut-offs as specified by the American Diabetes Association, 5.7 6.4%. 1 This cut-off has been shown in a meta-analysis to be predictive of progression to diabetes.
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Combining all three types of metastatic breast cancer, we asked whether elevated concentrations of these various subtypes would be predictive of progression-free survival or overall survival (OS) as determined by KM estimator analysis.
Ninety-two subjects had matched cytologic/histologic pairs at study termination, which were compared to determine whether cytologic testing was predictive of progression.
Supplementation of diagnostic criteria with biomarkers that are causally related to SCZ or endophenotypes may allow definition of homogeneous subgroups that are predictive of progression and therapeutic response in individual patients [20] and would serve as a starting point for development of therapeutics directed at causal variants.
Interestingly, the detection of glomerular C3 within a renal biopsy is predictive of progression of renal disease.
In the only RCT examining this topic to date, tidal volume was predictive of progression to ARDS.
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