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Hand grip strength has shown to be predictive of major health-related events in older persons[ 15, 29].
ScVO2 seems to be predictive of major outcome in severe head trauma but not in moderate head trauma.
For example, the diagnosis of left ventricular hypertrophy (LVH) has been demonstrated to be predictive of major cardiovascular events, including stroke and all-cause mortality, independent of BP.
The aim of this study was to explore the hypothesis that the lowest central venous oxygen saturation and the peak lactate value during cardiopulmonary bypass, used alone or in combination, may be predictive of major morbidity and mortality in pediatric cardiac surgery.
In a retrospective analysis of 256 pediatric (<6 years old) patients submitted to cardiac surgery, Ranucci and colleagues evaluated whether the lowest ScvO2 and the peak lactate value during cardiopulmonary bypass, alone or in combination, may be predictive of major morbidity and mortality [ 23].
Notably, in a recent study, gene expression patterns were shown to be predictive of major cytogenetic patterns seen in meningiomas (chromosome 22 or 22q loss, loss of 1p36 alone, complex karyotypes with loss of 1p36 and/or 14q and diploid) based upon altered expression of a combination of genes within the regions of altered dosage and genes outside these regions [ 42].
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A post hoc analysis of the TNT study demonstrated that the HDL cholesterol level was predictive of major cardiovascular events also in patients receiving statins (19).
Furthermore, Barter et al. [ 9] have demonstrated that HDL-cholesterol levels are predictive of major cardiovascular events in statin-treated high-risk patients for CVD with low LDL-cholesterol levels.
Similarly, in a cohort of 211 high-risk patients undergoing emergency non-vascular surgery, Oscarrson et al. found elevated post-operative cTnI, in the absence of acute ECG changes, was predictive of major adverse cardiac events and 30-day mortality [ 18].
A post hoc analysis of the Treating to New Targets (TNT) trial conducted in 2,661 subjects achieving LDL-C <1.8 mmol/l (70 mg/dl) during treatment with atorvastatin 10 or 80 mg/day showed that HDL-C levels were predictive of major CV events across the entire cohort, both when HDL-C was considered a continuous variable and when subjects were stratified according to HDL-C quintile [ 56].
The strain distribution along the anterior cortex, the major load-bearing pathway in flexion, may be predictive of impending VCF.
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