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KRAS mutation also is reported to be predictive for poor prognosis and low survival rate in cancer [ 22, 25, 29].
Although increased levels of IL-6 seem to be predictive for poor survival and increased infectious complications [ 25].
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Univariate analysis showed that high GRK2 expression in tumor tissues was predictive for poor overall survival of PC.
In this cohort of OC patients, high serum sCXCL16 levels were predictive for poor survival.
Abnormal accumulation of p53 in breast cancer tissue is predictive for poor prognosis [ 1, 2].
This "wound healing signature" was predictive for poor overall survival and increased risk of metastasis in breast, lung, and gastric cancers [ 13, 14].
To further investigate this issue we correlated the SOX2 expression with previously published data on CD133, an established marker for CSC which is predictive for poor prognosis and distant spread in CC [ 31- 33].
Among the parameters being predictive for poorer outcome in certain patient sub-groups were higher tCho/Cr and tCho/NAA ratios and higher lipid signals and lower Cr/NAA ratio [ 17].
HER2 overexpression on DTC in BM was predictive for a poor clinical outcome of stage I to stage III breast cancer patients [ 54].
The overexpression of RAD52, along with RAD51 and TOP2A, all three DNA repair genes, has been reported to be predictive of poor relapse-free survival for melanoma 37.
Our findings suggest that S100A14 and S100A16 protein expression may be predictive biomarkers for poorer prognosis of breast cancer patients.
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