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To facilitate the assessment of A-1210477 and its related indole-2-carboxylic acid analogs, we sought to identify MCL-1-dependent cell lines that would be predicted to undergo apoptosis in response to these agents.
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As one can see in the figure above, certain sectors are predicted to undergo much greater growth than others.
Upon processing, small droplets (<5 μm) are predicted to undergo volumetric precipitation and form solid particles prior to impact at the deposit location.
These are novel structures that are predicted to undergo self-assembled and to form stable 'zippers', which should be amendable to molecular manipulations that change the physical properties of the supramolecule, while preserving the three-dimensional structure.
At a pressure of roughly two megabars and a temperature of about 6,000 K (10,300 °F, 5,730 °C), the fluid molecular hydrogen is predicted to undergo a major phase transition to a fluid metallic state, which resembles a molten alkali metal such as lithium.
The reasoning for this novel design concept to omit the thick soft copper interlayer, which has been used as stress-relaxing buffer between the stiff armor block and tube, is to prevent plastic fatigue damage under cyclic high heat flux loads and irradiation embrittlement which the soft copper interlayer is predicted to undergo.
The large scattering length leads to two-state mixtures which are predicted to undergo a transition to a superfluid state at a relatively high temperature.
As basic mechanisms of intracellular transport are generally conserved (Bonifacino and Glick, 2004), coatomer is predicted to undergo a similar large conformational change during membrane recruitment.
In addition, all the tested compounds were predicted to undergo a maximum of 4 metabolic reactions, which is within the acceptable range for "drug-like" compounds.
Exon analysis shows that the two N-terminal glutamic acid-rich sequences which are predicted to undergo conformational change upon binding of calcium, as well as the C-terminal EF-hand Ca2+-binding domain are each encoded by a single exon.
Climate Change to Impact Ocean Health: Every inch of the world's oceans are predicted to undergo chemical changes associated with global climate change by 2100, according to research published in the journal PLOS Biology.
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