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Similarly, tumours with AKT1 mutation would not be predicted to respond to PI3K inhibitors.
16 Patients exhibiting primary non-responsiveness to TNF inhibitors are likely to have non-TNF-α-mediated disease and consequently would be predicted to respond better to subsequent therapy with an alternative mode of action.
Populations of herbivorous insects would be predicted to respond to higher foliar N concentrations and decreased foliar defenses in nitrogen-rich soil indicator plants by increasing individual and population growth rates [ 50, 51].
A common disease in this setting that is easily confused with leptospirosis is scrub typhus; both diseases would be predicted to respond to doxycycline, an antimicrobial drug often prescribed for undifferentiated fever.
FcRL5 has been recently shown to bind to Fc of Ig (Wilson et al., 2012) and would be predicted to respond to environmental changes in the levels of immune complexes.
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For example in L. plantarum, Lp_0188 (SacR) is predicted to respond to sucrose or oligofructose, a prediction that was derived from experimental evidence obtained for orthologous TFs [ 67- 69].
Rather it defines a suite of pressure scenarios that accommodate uncertainty in these aspects, and seeks to identify indicators that are predicted to respond in a consistent fashion across these scenarios.
These can be prepared semi-synthetically by covalent coupling to single cysteine mutations introduced at positions where the fluorophore is predicted to respond to formation of the complex without adversely affecting the interaction.
The resulting calculation showed that the time t, when the maximum number of neurons, that were born after the DG network was fully formed, contribute to spatial information processing, is at day 217, where 2057 of the adult-born neurons in the sample region are predicted to respond to spatial exploration (Fig. 5D).
Based on MHC binding affinity algorithms, mice expressing H-2b were predicted to respond poorly to α-Syn epitopes; yet 21 days after chronic MPTP-intoxication, B6 mice that express the H-2b haplotype yielded significant antibody responses to N-α-Syn.
In addition to these genetic candidates, our NEO analysis identified over 100 genes in the module that are predicted to respond to Cd44.
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