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Activation of SCD in animals lacking normal leptin signaling can thus be predicted to lower the cellular susceptibility to toxic palmitate concentrations.
Through a regression analysis, the full-dose nut intake would be predicted to lower LDL cholesterol by −0.26 mmol/L (−0.42 to −0.10).
The higher pHi of cancer cells is paradoxical because increased production of metabolic acids generated by aerobic glycolysis would be predicted to lower pHi.
Since all three SODs catalyse the same reaction of O2− to H2O2, it cannot simply be the expected change in the reactant side of the redox balance leading to up-regulation of SOD1 and SOD2, as reducing the amount of O2− and increasing the amount of H2O2 with regain of SOD3 would be predicted to lower the overall need for SOD1 and SOD2.
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Reducing Aβ production is predicted to lower plaque burden and mitigate AD symptoms.
This premium reduction is predicted to lower the annual premium for homeowners by around $900, and will hopefully enable a quarter million new buyers to purchase a home.
A previous study showed that a single point mutation to one of the fragments of a complemented protein, which was predicted to lower the affinity between the fragments, reduced background activity [37].
The p.W325C mutation reduces this edge-to-face interaction and is predicted to lower the stability of the protein.
Increased internal capsid pressure due to genome maturation together with capsid oxidation is predicted to lower the energy barrier to disassembly.
To monitor nonrandomness of predictions to increase the receptor affinity to IFN- γ, we selected a smaller set of variants that were predicted to lower the receptor affinity.
We can evaluate the performances of potential derivatives of INH and RIF by modifying key PK and PD properties and quantifying the extent to which these derivatives are predicted to lower bacterial load, shorten Ts and lower treatment failure rate (Fig. 4b).
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CEO of Professional Science Editing for Scientists @ prosciediting.com