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Such binding would be predicted to decrease the volume accessible to substrate, thereby reducing the degrees of freedom available for its positioning and so increasing the probability that it will adopt a proteolysis-competent conformation (see [25]).
Increased fasting-state hepatic glucose uptake, use and disposal by GCK in the presence of P446L-hGKRP would be predicted to decrease circulating plasma glucose concentrations.
On the basis of previous studies [ 12, 14, 32, 33], connectance can be predicted to decrease with increases in the total number of species and habitat area.
As noted above, even if there were modest uncoupling, this would be predicted to decrease ROS production rather than increase it.
While a multivariate analysis indicated a joint effect of AKI on both KLK1 excretion and urine KLK1 CpG methylation, elevated KLK1 methylation would be predicted to decrease KLK1 excretion in AKI, as occurs in early/incipient AKI.
In the short term this would be predicted to decrease actin filament turnover, as reported by Star et al., while over longer times this impaired actin turnover may contribute to the spine shrinkage and synapse loss that we observe.
Similar(46)
The amino acid substitution is predicted to decrease protein stability, and the prediction confidence is 76.34%.
Decreased flux through the PPP is predicted to decrease antioxidant capacity through lower NADPH production, an effect consistent with the down-regulation of other anti-oxidant pathways discussed above.
Decreased expression of HMGB2 in CRPC is predicted to decrease expression of at least a subset of androgen-regulated genes that contain palindromic AREs [ 111].
The mean change in species' mean state-wide probability of occurrence was also greater for Maxent-based predictions than for GAM-based predictions, as was the number of species whose distributions were predicted to decrease.
"The veteran population is predicted to decrease in the next 20 years in Manhattan," Mr. Mazzulla said.
More suggestions(17)
be estimated to decrease
be anticipated to decrease
be predicted to fall
be predicted to localize
be attributed to decrease
be predicted to exacerbate
be done to decrease
be predicted to cause
be predicted to improve
be predicted to initiate
be manipulated to decrease
be improved to decrease
be predicted to produce
be predicted to lose
be predicted to impede
be targeted to decrease
be predicted to sell
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Justyna Jupowicz-Kozak
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