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Our analysis revealed that multiple K-channel subfamily members are often co-regulated at the exclusion of other members or subfamilies that would be predicted to confer similar properties.
Underlying defects in DNA repair would be predicted to confer increased sensitivity to DNA damaging cytotoxic drugs such as cisplatin.
In addition, the loss of HIF-independent VHL-mediated suppression of targets such as cyclin D1 (Zatyka et al, 2002) or SP1 (Yuen et al, 2007) would be predicted to confer a more aggressive phenotype.
Mutations in these genes, others in their pathways, and genes of the DNA-damage response are probable or known in many cancers and might be predicted to confer TLD resistance.
The sequence of contigs directly reflects the sequenced gene space, which is especially important for a species like pennycress where this information enables one to identify genes of interest whose manipulation via either overexpression or knockdown can be predicted to confer agronomically desirable phenotypes.
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Consistent with previous studies, mutation K101P is predicted to confer high-level resistance to DAPYs.
Calculated optimum conditions were predicted to confer a 100% yield of keratinase activity with 5 mM CaCl2, pH 8.0 and at a temperature of 40 °C.
We provide evidence here that the genetic bottleneck imposes a selection bias for transmission of amino acids that are consensus in the cohort and are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naïve recipient.
We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naïve recipient.
Both mutations are predicted to confer amino acid changes but their impact on gene function is unknown.
Collectively, this transcriptional response is predicted to confer a strong pro-death signal in the tumor cells.
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