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Tf might be predicted to act as an indicator of growth within the cells and tissues of the host, rather than on the epithelial surface, while Hb would be primarily indicative of a location with a serous exudate or within the vascular compartment.
Given evolutionary conservation across vertebrate taxa, both human and veterinary pharmaceuticals may be predicted to act on many non-target species [ 4].
MMP-19 can degrade various ECM proteins in vitro and, thus, could be predicted to act in an anti-fibrotic manner by promoting breakdown of the ECM.
Pseudo-DUBs may be predicted to act in a dominant-negative manner preventing other DUBs from gaining access to their substrate, or alternatively they may bind ubiquitylated proteins and play a scaffolding role in protein protein interactions.
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Therefore, 5-sulfosalicylic acid was predicted to act as dopant during electropolymerization and as ionophore in the course of potentiometric determination of cupric ions.
18F-FAMT was predicted to act as a specific radiotracer of brain tumor tissue based on the low uptake by normal brain tissue compared with 18F-FDG and has proven specificity to detect gliomas [15].
THZ and related compounds are predicted to act via the emrE-encoded efflux pump [10], [11], [51].
For directly transmitted pathogens such as SNV, contact rates between infected and susceptible individuals represent the underlying mechanism through which diversity is predicted to act.
The result is remarkably similar to a previous report in which nearly 30% of apoplastic proteins are predicted to act on polysaccharides of the cell wall in Arabidopsis [8].
Tyr493 is the only Tyr residue of this segment and thereby the candidate for covalently binding the potent inhibitor NBD-Cl, which was predicted to act as a nucleotide analogue in F1FO ATP synthases [50].
Although such strong effects were not observed upon depletion of CG10075 (Table 2), which is predicted to act as an ubiquinol-cytochrome c chaperone in mitochondria, these results suggest that energy depletion and/or other mitochondrial dysfunction upon downregulation of these genes affect the functional organisation of the early secretory pathway.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com