Due to the relative small population sizes, it is predicted that human gene sequences are not strongly influenced by selection towards expression efficiency.
It has been predicted that human NRF1 gene may transcribe at least four different transcripts with alterative first exons, differential splicing, and alterative polyadenylation (Biswas and Chan 2010).
So much so that even the UN, not normally all that up to date on these sorts of things, is predicting that human population in 2100 will be lower than it will be in 2050, or even than it is today.
Furthermore, if it turns out that the human JAK2V617F protein is fully functional in the mouse environment, then it would be predicted that mice expressing homozygous human JAK2V617F would produce a PV-like phenotype.
It is predicted that the human complement of PPIs (the interactome) numbers between 130,000 and 600,000 [ 1, 2].
It is predicted that in humans, over 80% of genes are alternatively spliced [2].
Population genetic data also indicate that some predicted 'loss-of-function' variants are also common in human populations: it has been predicted that a typical human is homozygous for approximately 20 such variants [ 25].
Using computational algorithms it was predicted that miRNAs regulate about 30% of human genes [4], but a recent inspection of human 3'UTR has shown that more than 60% of protein-coding genes maintain conserved target sites for miRNA recognition [5].
In humans, it is predicted that the colonizing bacteria would next progress to synthesis of the primary virulence factors CT and TCP, resulting in the onset of cholera disease, generally 1 5 days after exposure to the bacterium [21].
