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To fulfill their promise, the fate, function, and organization of hPSCs need to be precisely regulated in a three-dimensional (3D) environment to mimic cellular structures and functions of native tissues and organs.
Therefore, while Fgf signalling is essential to initiate blastema formation and growth, the level of Fgf expression must also be precisely regulated in order to limit the regeneration process.
Moreover, these processes must be precisely regulated in space and time.
Therefore, the MIWI/piRNA system appears to be precisely regulated in a highly stage-specific manner in spermatogenesis.
Light-mediated regulation has the huge advantage over temperature or chemicals that it can be precisely regulated in quantity, space and time, at least at the level of micro-organisms or cell cultures.
Goddeeris et al. (2013) demonstrated that the length of the matriglycan chain synthesized by LARGE varies over the course of muscle regeneration, suggesting that the structure to which the ECM ligands bind directly may have to be precisely regulated in vivo.
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To sum up, intracellular pH is precisely regulated in cells to ensure proper cellular physiology.
Under physiological conditions their activity is precisely regulated in order to prevent tissue disruption.
In the present study, we reveal a novel mechanism to clarify how inflammation is precisely regulated in human rheumatoid arthritis synovial cells.
Taken all these indicated that Wnt- β-catenin signaling is precisely regulated in a number of embryonic developmental processes, and Wif1 modulates the Wnt- β-catenin signaling activity.
Although ADAR1 and ADAR2 are the sole factors needed to catalyse RNA editing in vitro [ 64, 65], it is apparent that the activity and selectivity of ADARs in cells are precisely regulated in a multifactorial manner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com