These findings suggest that GABAergic and glutamatergic synaptic contacts on GnRH neurons in cycling young animals are precisely regulated, and that the decrease in GABAergic and increase in glutamatergic synaptic contacts on GnRH neurons on proestrus may serve to facilitate GnRH neuron activation on the day of the preovulatory LH surge.
In a healthy person, bone turnover is precisely regulated and occurs on a constant basis.
During neuronal development, ATP7A expression over time is precisely regulated, and varies according to cell type (Linz and Lutsenko, 2007).
The HPT axis is precisely regulated and it is plausible that the low environmental exposures experienced by the U.S. population do not substantially influence individual thyroid profiles.
During bronchogenesis in the developing lung, Sox2 is precisely regulated and forced overexpression of Sox2 leads to a block of airway branching [ 5].
The expression and activity of the replication licensing factors are precisely regulated, and misexpression or mutation of these factors can lead to DNA re-replication, genome instability, major chromosomal rearrangements, and tumorigenesis (Melixetian et al., 2004; Green and Li, 2005; Rice et al., 2005; Hook et al., 2007; Liontos et al., 2007; Sugimoto et al., 2009; Green et al., 2010).
Because Notch gene products need to be precisely regulated spatially and temporally, epigenetics is likely to help control expression of Notch signaling genes.
Our results indicated that tubule fission, endosomal acidification/motility along the microtubule, and perinuclear localization, which happen between the early endosomal state and degradation, took place in a defined order and could be precisely regulated (Fig. 5E and Table 1).
Moreover, these processes must be precisely regulated in space and time.
