A large deletion originally reported in Filipinos and known as the 45 kb deletion [6], [7] has a defined upstream breakpoint between the δ and β-globin genes, however its 3' end breakpoint had not yet been precisely characterized and remains unknown.
The genetic defect in scurfy mice is precisely characterized and affects only Foxp3+ Tregs; consequently, all pathological features described in scurfy mice can be attributed to the lack of Treg control.
The parameters of the EA can be precisely characterized, so it is reproducible, and data suggest that EA may be more effective than manual acupuncture [ 3].
Moreover, in addition to steady-state levels, the transient regimes following media switch can be precisely characterized by measuring the parameters δ and γ.
Indeed, knowledge about the perfect and most appropriate parameterization is often not available or easily obtainable when performing in-depth sequence analysis, and, sometimes the 'correct' parameters may never be precisely characterized due to the complex nature of the experiment.
Furthermore, the shear deformation effect and the rotary inertia effect cannot be neglected in nanobeams with a relative small aspect ratio, which cannot be precisely characterized by the Euler Bernoulli beam theory.
Thus, by combining our approach with in vitro monoclonal antibody-mediated neutralization assays, masking of specific mAb targeted epitopes can be precisely characterized.
In the present study, single base flipping from a DNA double helix is used as a test case to point out how a structural change can be precisely characterized using free energy landscape analysis.
If sub-populations could be precisely characterized, this would facilitate the use of the most appropriate cell therapy in future clinical trials [ 16].
Lipophilicity is precisely characterized by the reference partition coefficient and, therefore, three levels of lipophilicity are distinguished in Figure 7. Amphiphilicity is considered in a semi-quantitative way, with high magnitudes expected for compounds with separated polar and nonpolar parts, and low magnitudes otherwise.
