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Similarity, we will not be powered to examine differential effects by study site.
A limitation of the study is that it will not be powered to examine heterogeneity of effect by sex or site.
Our trial could not be powered to examine preeclampsia or eclampsia because the population of The Gambia is too small to have generated sufficient incidence rates for these outcomes.
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Early studies have not been powered to examine these clinically important outcomes.
We note that our trial with a sample size of 400 was relatively small and was powered to examine the effect of multivitamin supplementation on only three endpoints.
This will enable valuable hypothesis generation which can be tested within the wider longitudinal study which is powered to examine causal processes.
The study was powered to examine the association between MR and TTP status using standard tests of association (Pearson's χ test of association, Fisher' exact test).
The study is powered to examine quality of life outcomes and uses an unbalanced allocation to examine the effect of the EDGE (sElf management anD support programme) platform across a wide range of participants.
The study was powered to examine main effects of incentives on response rates, and we may have made Type II errors when examining secondary outcomes, effects of the different tracking/privacy conditions, and potential interactions.
Large well-controlled observational studies that are powered to examine important subgroup effects (for example, RBC transfusion by hemoglobin concentration) and time-varying covariates (for example, ICP) are warranted to characterize both hemoglobin concentrations and transfusion thresholds to guide clinicians managing patients with a TBI.
The increase in pulmonary inflammation observed after HSCT may be a consequence of either the conditioning or the result of an immunological or inflammatory response to the allograft, and the absence of a consistent difference between the two conditioning groups suggests that the latter explanation may be more likely, although the study was not powered to examine these differences.
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CEO of Professional Science Editing for Scientists @ prosciediting.com