Animal experiments indicate that reactive oxygen species (ROS), which have established relevance in the pathogenesis of cardiovascular disease (Dhalla et al. 2000), are potential mediators for particle effects on HRV and other cardiovascular end points (Brook et al. 2004; Gurgueira et al. 2002; Nel 2005; Rhoden et al. 2004).
Here, we aimed to leverage these findings in an attempt to filter out epigenetic marks resulting from disease, focusing our attention on the identification of epigenetic marks that are potential mediators of genetic risk for EOC.
Small RNA pathways are potential mediators of this effect.
Another limitation is that adjustment for variables that are potential mediators, such as hypertension in the multivariate model, may be an overadjustment, and therefore may have led to an underestimation of the true association between serum perfluoroalkyl chemical levels and uric acid.
Close monitoring of patients after surgery might help to identify patients who could benefit from adjunctive treatment for psychiatric disorders as post-surgery psychiatric symptoms may be a potential mediator for poorer quality of life outcome after surgery.
Our study further indicates that miR-34c has tumor-suppressive effects in breast cancer and, together with other reports, this implies miR-34c to be a potential mediator for novel miRNA replacement therapies [ 50].
During this time, substantial clinical and epidemiological measures were collected, and a number of these were assessed as potential mediators for our genetic associations.
Mediation analyses further revealed that prenatal maternal cortisol levels were a potential mediator for the relationship between maternal symptoms of depression and both gestational age at birth and the rate of fetal growth.
TGF-β produced by keratinocytes in response to UVB (290 320 nm) is a potential mediator for effects of acute and chronic solar radiation on skin.
All these mediators may be potential targets in PDR treatment.
