Sentence examples for be potent and efficacious from inspiring English sources
AGSMs were shown to be potent and efficacious in vivo in decreasing the levels of Aβ42 and Aβ40 in both the plasma and brain of APP transgenic mice, and chronic efficacy studies revealed that AGSMs dramatically attenuated AD-like pathology in the Tg2576 APP transgenic mouse model.
These results show TNFR2 antibodies are potent and efficacious in vitro.
Nevertheless, RepliVAX is potent and efficacious in animal models for WNE and Japanese encephalitis, demonstrating its utility as a third‐generation flavivirus vaccine that should be potent, economical to produce, and safe in the immunocompromised.
G00033054 and GDC-0973 are potent and selective MEK inhibitors that have been efficacious in treating KRAS and RAF mutant cells [29].
Both were potent and poignant.
A lead compound 21 was found to be a potent and efficacious GPR119 agonist across species, and possessed overall favorable pharmaceutical properties.
Somewhat unexpectedly, TCDD was found to be a potent and efficacious inducer of testosterone 6β-hydroxylation (EC50 = 0.154 ± 0.03 nM, maximal rate = 2830 pmol/min/mg protein; Figure 3B).
It has also been suggested that opioid agonists can be less potent and efficacious in females than males [ 28]; however, the data may depend on species, disease process, and age [ 29, 30].
In aorta, the PPARβ/δ agonist, GW0742, was an active vaso-relaxant, but was less potent and efficacious than in pulmonary artery.
This resulted in quipazine changing from being effectively an antagonist in wild type receptors, to being a potent and efficacious agonist in mutant receptors, and VUF10166 becoming an agonist in mutant heteromeric receptors with an EC50 value 230-fold lower than the EC50 for 5-HT in wild type receptors.
