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Whittlesey notes that the models are preliminary, so even greater improvements might be possible with further study.
Although we did not intend to rigorously qualify the LAMP assay for malaria here, these results suggest that a quantitative assay with a clinically significant lower limit of detection and three decade dynamic range might be possible with further development of the protocol.
Improved cross-species genomic analyses will be possible with further genome annotation and sequence similarity assessments [ 28].
Thus, It might be possible, with further research, to use CREB3L1 as a biomarker to identify tumors that are suitable for treatment by doxorubicin.
We used standard assay procedures, using undiluted eluates from oral swabs and DBS; improvements to sensitivity may be possible with further optimization of the serological and NS1 antigen assays for oral swab samples.
However, since cancerous glands appear to have distinctive cytologic and architectural features on CARS imaging, especially in higher grade tumors (Gleason pattern 4 or 5), it may be possible, with further study, to identify criteria that would enable pathologists to render real-time diagnoses of carcinoma using CARS images alone, at least in some instances, without frozen sectioning analysis.
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Deeper insights are possible with further analysis of multichannel EEG [ 55– 58].
However, the case report published in this edition of the British Journal of Cancer suggests this may be possible with docetaxel and requires further investigation.
The use of multiple imaging methods provides improved outcomes, and further improvements will be possible with future studies of larger patient cohorts.
This study demonstrates, for the first time in a large-scale validation, that rigorous free energy calculations can be used to predict changes in protein stability from point mutations without parameterization or system-specific customization, although further improvements should be possible with additional sampling and a better representation of the unfolded state of the protein.
Further precision may be possible with more detailed (genomic scale) genetic data and a search for archaeological specimens, which themselves may be subject to genetic analysis.
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