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As a better understanding of the mechanisms that regulate NKT cell function is achieved and as novel ligands that can specifically modulate these functions are generated, it may be possible to specifically boost these types of responses in vivo.
By maintaining this line of thought it might be possible to specifically engineer fragility in such a manner that the synthetic organisms are 'evolutionary losers'.
If this is so, it might be possible to specifically reactivate or potentiate TGF-β-induced growth arrest in human cancers without altering other TGF-β responses.
Because CFTR and P-gp are predicted to be structurally similar, it may be possible to specifically repair CFTR processing mutants by a direct drug rescue approach using small molecules.
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With these thermal methods, it is possible to specifically detect noradrenaline in aqueous solutions and quantify it at relevant concentrations.
By transducing the Crb1−/− mouse retina using AAV2/6 vectors in combination with the GFAP promoter, we demonstrate that it is possible to specifically express transgenes in activated Müller glial cells, without expression in retinal ganglion cells, amacrine, bipolar, horizontal or photoreceptor cells.
Their work suggests that it is possible to specifically target neuropilin internalization.
By having a dedicated compartment of stem cells, it is possible to specifically respond to the requirement of the infundibulum for constant repair.
With the masses of each substrate being known, it was possible to specifically detect the mass of predicted hydroxylated (+16 amu) and N-demethylated products (−14 amu).
Interestingly, the DsRed emission was completely abolished after separation of the two fluorophores demonstrating that it is possible to specifically excite the donor and separate the emissions of the donor and acceptor molecules completely using this combination of fluorescent proteins.
Proof-of-principle compounds show that it is possible to specifically inhibit individual RING finger and F-box ubiquitin ligase complexes as well as their antagonists, the de-ubiquitinating enzymes (Micel et al, 2013).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com